Dibutyl phthalate induced testicular dysgenesis originates after seminiferous cord formation in rats
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چکیده
منابع مشابه
Human 'testicular dysgenesis syndrome': a possible model using in-utero exposure of the rat to dibutyl phthalate.
BACKGROUND The disorders comprising human 'testicular dysgenesis syndrome' (TDS) may be increasing in incidence. TDS originates in fetal life but the mechanisms are not known, and discerning them requires an animal model. METHODS AND RESULTS The study investigated whether male rats exposed in utero to dibutyl phthalate [DBP; 500 mg/kg on gestational days (GD) 13-21] would provide a suitable m...
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The testicular dysgenesis syndrome (TDS) hypothesis, which proposes that common reproductive disorders of newborn and adult human males may have a common fetal origin, is largely untested. We tested this hypothesis using a rat model involving gestational exposure to dibutyl phthalate (DBP), which suppresses testosterone production by the fetal testis. We evaluated if induction of TDS via testos...
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activity in liver homogenate from di-2-ethylhexyl phthalate (DEHP)-treated rats. Ohyama9) showed in vitro that PAEs inhibited mitochondrial respiration, with di-n-butyl phthalte (DBP) showing the strongest effect, and he concluded that PAEs were inhibitors of electron and energy transfer systems but not uncouplers. Takahashi10) also found inhibitory effects of PAEs on respiration in vitro and a...
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Introduction: The aim was to investigate the protective effect of the Syzygium aromaticum extract on damaged tissues and the oxidative stress after testicular torsion. Methods: Rats were randomly divided into a control group subjected to a sham procedure and three treatment groups comprising testicular torsion followed by detorsion (TD), testicular torsion detorsion followed by the tre...
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ژورنال
عنوان ژورنال: Scientific Reports
سال: 2017
ISSN: 2045-2322
DOI: 10.1038/s41598-017-02684-2